(2017). (2014). Therefore, comprehensive benefit and risk assessment for elderly patients undergoing H. pylori eradication treatment are essential. We would like to thank YZ provided the funding by grants from the National Natural Science Foundation of China (No. 74 (6), 1718–1724. Maintenance dose: 80 mg via IV infusion every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes. In the BQT group, the frequency of side effects was 26.6% (20/75) of patients (p = 0.026). doi:10.1136/gut.2009.192757, Graham, D. Y., Javed, S. U., Keihanian, S., Abudayyeh, S., and Opekun, A. R. (2010). Our study followed the recommendations of the Consolidated Standards of Reporting Trials (CONSORT) statement for reporting randomized controlled trials. Continuous variables are expressed as the mean ± standard deviation, and categorical data are presented as absolute numbers and percentages. If you are taking the granules, take your dose 30 minutes before a meal. 101.2019). Clinicians can choose this treatment when considering H. pylori eradication in elderly patients. Clin. male or female patients aged ≥60 years; 2) patients diagnosed with H. pylori infection by positive C-urea breath test (UBT) or by positive gastric mucosa biopsy results (UBT results between 4‰ and 6‰ were not included in the group, as well as those who remained above 4‰ after 7 days of reexamination); 3). Nausea, diarrhea, and abdominal pain were the most frequently occurring adverse events. Uses. Urinate into the toilet if needed . Pharmacol. alcohol abuse (daily alcohol intake exceeding 50 G for more than 6 months); 4). Received: 11 November 2022; Accepted: 23 January 2023;Published: 01 February 2023. Detailed inclusion criteria were as follows: 1). Zullo, A., Ridola, L., Francesco, V. D., Gatta, L., Hassan, C., Alvaro, D., et al. doi:10.1007/s10238-020-00643-2, Kwack, W., Lim, Y., Lim, C., and Graham, D. Y. Pract. Written informed consent was obtained from all participants. doi:10.1111/hel.12475, Malfertheiner, P., Megraud, F., O'Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T., et al. Properly discard this product when it is expired or no longer needed. doi:10.1097/MD.0000000000014396, Yu, L., Luo, L., Long, X., Liang, X., Ji, Y., Graham, D. Y., et al. Zegerid OTC . doi:10.1111/hel.12596, Zhang, Y., Zhu, Y. J., Zhao, Z., Zhao, J. T., Wang, T. Y., Yang, J., et al. Clin. Background: Currently, the management of Helicobacter pylori (H. pylori) infection in elderly patients is controversial. Common pantoprazole side effects may include: headache, dizziness; stomach pain, gas, nausea, vomiting, diarrhea; joint pain; or. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Die meisten kommerziellen Testsysteme haben eine halbwegs gute Sensitivität (93,3%) sowie Spezifität (93,9%) für den Nachweis dieser Infektionen, wobei. No adjustment recommended. Der H. pylori Stuhl Test ist ein visueller Immunoassay für den qualitativen Nachweis von H. pylori Antigen in Stuhlproben. Tell your doctor if your condition lasts or gets worse. Take your next dose at the regular time. The compliance rates was 98.7% (74/75) in the HT group and 97.3% (73/75) in the BQT group. Take this medication by mouth as directed by your doctor, usually once daily. 381 (9862), 205–213. doi:10.1007/s00535-010-0220-x. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum™ (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. High-dose PPI-amoxicillin dual therapy with or without bismuth for first-line Helicobacter pylori therapy: A randomized trial. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse. 15 to less than 40 kg: 20 mg orally once a day Background: Short-term, low-dose triple regimens composed of proton-pump inhibitors (PPI) and two antibiotics are the current gold standard therapy for cure of Helicobacter pylori infection. The purpose of this study was verify whether HT could achieve a similar effective eradication rate to BQT in elderly patients. Helicobacter 25 (6), e12762. Safety and efficacy for uses otherwise described (e.g., life-threatening gastrointestinal bleeds) are not available; however, use of this drug at 40 mg/day doses did not raise gastric pH to sufficient levels to contribute to the treatment of life-threatening conditions. This medication may interfere with certain laboratory tests (including urine test for tetrahydrocannabinol-THC, blood test to find certain tumors), possibly causing false test results. doi:10.1093/jac/dkz046, Unge, P., Gad, A., Gnarpe, H., and Olsson, J. A follow-up study. Side effects and compliance were assessed using a questionnaire administered after the end of therapy. Individual treatment needs to be performed in elderly patients. Guten Tag, mein Arzt vermutet mittlerweile bei mir eine Magenbesiedlung mit Helicobacter Bakterien.Um dies herauszufinden, hat er eine Stuhlprobe genommen. All adverse events disappeared spontaneously after treatment. However, there is currently no consensus or guideline on H. pylori eradication therapy in elderly patients. Diagnostic tests used in the primary care office include serology and stool antigen tests, whereas the urea breath test and gastric biopsies require subspecialist referral. In the ITT analysis, H. pylori was eradicated in 89.3% of patients (67/75) (95% Cl: 82.2–96.5) in the HT group compared with 86.6% (65/75) (95% Cl: 78.8–94.5) in the BQT group (Table 2). Nexium . gastroenterology 28 (4), 448–451. Does omeprazole improve antimicrobial therapy directed towards gastric Campylobacter pylori in patients with antral gastritis? Treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, Pathological hypersecretion conditions, including Zollinger-Ellison syndrome, Short-term treatment of GERD in patients with a history of EE, Acid output target range: Less than 10 mEq/h, Hypersensitivity to the active component, substituted benzimidazoles, or any of the ingredients, Patients receiving rilpivirine-containing products. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The risk of side effects goes up over time. Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: A multicentre, open-label, randomised trial. doi:10.1097/00004836-198606002-00010, Fu, J., Sun, C. F., He, H. Y., Ojha, S. C., Shi, H., Deng, C. L., et al. Am. Last updated on Dec 26, 2022. US residents can call their local poison control center at 1-800-222-1222. Allerdings hatte er mir einige Tage zuvor Pantoprazol verschrieben. TABLE 1. Short-term treatment in the healing and symptomatic relief of EE. (2018). (2020). Stuhltest auf Helicobacter pylori. Many people using this medication do not have serious side effects. Pantoprazole and bismuth were taken 30 min before breakfast and dinner, and amoxicillin and clarithromycin were taken 30 min after breakfast and dinner. Side effects were few although a minority of patients in the BQT group complained of vomiting due to clarithromycin. Oral: 40 mg orally 2 times a day. J. Clin. To overcome this problem, there are several novel therapies such as sequential therapy, non-bismuth quadruple therapy, and hybrid therapy that have achieved high eradication rates in first-line H pylori eradication (Liou et al., 2013; Liou et al., 2016). Maximum dose: 240 mg/day. (2019). Second, we did not measure the patients’ intragastric pH value or CYP2C19 genotype. doi:10.1111/hel.12692, Gao, W., Ye, H., Deng, X., Wang, C., Xu, Y., Li, Y., et al. (2016). doi:10.1080/07853890.2022.2031269, Song, Z., Zhou, L., Xue, Y., Suo, B., Tian, X., and Niu, Z. H. PYLORI BREATH TEST Patient Instructions STOP 2 WEEKS BEFORE YOUR TEST: PROTON PUMP INHIBITORS (PPI) Dexilant . Medically reviewed by Drugs.com. CYP450 2C19 Poor Metabolizers: The patients/participants provided their written informed consent to participate in this study. Pathological Hypersecretion (including Zollinger-Ellison syndrome): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Aging and upper gastrointestinal disorders. This document does not contain all possible drug interactions. If any of these effects last or get worse, tell your doctor or pharmacist promptly. J. Gastroenterol. Pantoprazole decreases stomach acid, so it may change how well these products work. Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: Studies from the United States. (2021). An improvement in acid inhibition extending into the nighttime hours, maintaining an intragastric pH of 6 or above, would greatly improve the eradication rates of a regiment (Marcus et al., 2012). doi:10.1097/MEG.0000000000001646, Zhu, Y. J., Zhang, Y., Wang, T. Y., Zhao, J. T., Zhao, Z., Zhu, J. R., et al. Inform patients that this drug may cause dizziness or blurred vision, and they should avoid driving or operating machinery if these side effects occur. Helicobacter pylori (H. pylori) infection and related diseases are a major global health concern. Approximately 53%–73% of elderly peptic ulcer patients are infected with H. pylori; however, elderly H. pylori-positive patients are less likely to receive treatment (Pilotto, 2004). Advise patients to avoid taking concomitant proton pump inhibitors and/or H2 antagonists during treatment. Gut 66 (1), 6–30. If your doctor instructs you to use this medication regularly for a long time, lab and/or medical tests (such as a magnesium blood test, vitamin B-12 levels) may be done while you are taking this medication. Efficacy of modified esomeprazole-amoxicillin dual therapies for Helicobacter pylori infection: An open-label, randomized trial. Some symptoms may actually be signs of a more serious condition. 2016, 1648047. doi:10.1155/2016/1648047, Leung, W. K., Wong, I. O. L., Cheung, K. S., Yeung, K. F., Chan, E. W., Wong, A. Y. S., et al. If you are giving the granules through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to properly mix and give it. Am. Moreover, H. pylori microbiology summarizes the existing evidence for first- and second-line treatment regimens that may be considered for special populations such as the elderly. 5 Add stool to the "FILL LINE".T ighten cap securely.. 2 : Lift toilet seat. Oral suspension/granule formulations should be taken on an empty stomach, preferably 30 to 60 minutes before a meal. In the HT group, 2 patients were lost to follow-up, and 1 paytient was not compliant with medications. High dose ilaprazole/amoxicillin as first-line regimen for Helicobacter pylori infection in korea. If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate. (2022). Amoxicillin is widely used in the treatment of H pylori infections; it is one of the most active antimicrobials against H pylori in vivo with a minimum inhibitory concentration of ≤0.01–0.1 mg/L (Hirschl and Rotter, 1996). Eradication efficacy of modified dual therapy compared with bismuth-containing quadruple therapy as a first-line treatment of Helicobacter pylori. Results: Successful eradication was achieved in 89.3% of the high-dose dual therapy (HT) group in the intention-to-treat (ITT) analysis, 91.7% in the modified intention-to-treat (mITT) analysis, and 93.0% for per-protocol (PP) analysis which was similar to the bismuth-containing quadruple therapy (BQT) group (86.6%, 87.8%, and 90.3%, respectively). Pharmacol. 23 (5), 275–280. Ann. Helicobacter pylori treatment in the era of increasing antibiotic resistance. 54 (1), 426–435. Read the Medication Guide provided by your pharmacist before you start taking pantoprazole and each time you get a refill. Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux). A multicenter study should be conducted to confirm our findings. However, the eradication rate was below 90%. If patients are not healed after 8 weeks with the oral formulation, treatment for another 8 weeks may be considered. Keep all medications away from children and pets. Ann. High dose PPI-amoxicillin dual therapy for the treatment of Helicobacter pylori infection: A systematic review with meta-analysis. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Doing so may destroy the drug. Symptomatic relief may occur after 1 day of treatment, but patients should continue treatment for the full duration to achieve complete symptom control. Adults: No adjustment recommended. patients who had taken antibiotics, bismuth, and PPIs within 4 weeks before initiating treatment; 3). Thus, a dual regimen with fewer antibiotics would be an option for older patients or those with multiple comorbidities. Ren, L., Lu, H., Li, H. Y., Zhu, L. Y., Xu, X. Q., Gu, L. Y., et al. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. It's a safe and easy way to detect H. pylori bacteria, diagnosis H. pylori infection, and determine if treatment cured the infection. If patients are not healed after 8 weeks or erosive esophagitis (EE) recurs with the oral formulation, treatment for another 8 weeks may be considered. The prevalence of upper gastrointestinal diseases is increasing in elderly populations worldwide. In conclusion, our data showed that a 14-day regimen with pantoprazole 40 mg 3 times daily and amoxicillin 1,000 mg 3 times daily achieved an H. pylori eradication rate of 89.3%. jxsq2019201028). In this respect, some meta-analyses showed higher HT effectiveness in studies in Asian countries than in European countries (Yang et al., 2019b; Gao et al., 2020a; Zhu et al., 2020). Therefore, we questioned whether high-dose and high-frequency amoxicillin-PPI dual therapy could be widely used in elderly patients. High-dose dual therapy is superior to standard first-line or rescue therapy for Helicobacter pylori infection. (Leung et al., 2018) demonstrated that among patients infected with H. pylori who received eradication therapy, the gastric cancer risk was significantly lower in the elderly compared with the matched general population highlighting the importance of eradication therapy for elderly patients. Most studies reported a low incidence of adverse reactions to PPI-amoxicillin dual therapy. The aim of this study was to evaluate the influence of pretreatment with pantoprazole on the efficacy of an ensuing triple therapy. WebMD does not provide medical advice, diagnosis or treatment. Some affected products include ampicillin, atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others. Statistical analyses to identify prediction factors were performed using SPSS 25.0 for Windows (SPSS, Chicago, IL). Do not store in the bathroom. To achieve a reliable cure rate, a high dose of PPI that is unaffected by CYP2C19 genotypes may be needed. Although dual therapy is not currently recommended as the first-line regimen for treating H pylori infection, many studies have reported an effective eradication rate of this regimen (Ren et al., 2014; Yang et al., 2015; Tai et al., 2019). Make sure laboratory personnel and all your doctors know you use this drug. doi:10.1136/gutjnl-2015-310142, Liou, J. M., Chen, C. C., Chen, M. J., Chen, C. C., Chang, C. Y., Fang, Y. J., et al. (2020). Testing is important for detection of Helicobacter pylori (H. pylori). In the PP analysis, H. pylori was eradicated in 93.0% of patients (67/72) (95% Cl: 87.0–99.1) in the HT group compared with 90.3% (65/72) (95% Cl: 83.3–97.3) in the BQT group (Table 2). Using the spoon attached to the cap, place stool into container. 36 (10), 972–979. Headache or diarrhea may occur. In May 2023, Frontiers adopted a new reporting platform to be Counter 5 compliant, in line with industry standards. High-dose rabeprazole-amoxicillin dual therapy and rabeprazole triple therapy with amoxicillin and levofloxacin for 2 weeks as first and second line rescue therapies for Helicobacter pylori treatment failures. Consult your doctor for more details. (2004). In Canada - Call your doctor for medical advice about side effects. Hepatol. gastroenterology 8 (32), 381–384. PPI-Amoxicillin dual therapy four times daily is superior to guidelines recommended regimens in the Helicobacter pylori eradication therapy within asia: A systematic review and meta-analysis. Applies to the following strengths: 40 mg; 20 mg. 5 years and older: Parenteral: Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes. Talk to your pharmacist for more details. Pilotto, A. Med. Gut 65 (11), 1784–1792. Select one or more newsletters to continue. Aliment. doi:10.1111/1751-2980.12186, Salles, N., and Mégraud, F. (2007). Alimentary Pharmacol. High dose dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication treatment: A systematic review and meta-analysis. There were no significant difference between the two groups regarding clinical characteristics. Flow diagram of this study. 70 (4), 176–180. The risk is increased if they are taken every day for a long time (3 years or longer). The trial was registered in the Chinese Clinical Trials Registration (chictr.org.cn), registered number is ChiCTR2000029679. patients who signed the informed consent form. Follow with sips of water. The effect of CYP2C19 gene polymorphism on the eradication rate of Helicobacter pylori by proton pump inhibitors-containing regimens in asian populations: A meta-analysis. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lupus. Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements. Short-term treatment of gastroesophageal reflux disease (GERD) in patients with a history of erosive esophagitis, Reduction of relapse rates of daytime and nighttime heartburn symptoms in adult patients with GERD, Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes, Maintenance dose: 80 mg via IV infusion every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes. However, according to some recent literature reports, increasing the dose of PPI and/or amoxicillin in the dual therapy regimen can effectively eradicate H. pylori (Goh et al., 2012; Attumi and Graham, 2014; Yang et al., 2015; Yu et al., 2019). No use, distribution or reproduction is permitted which does not comply with these terms. Uses: IV: Data not available Gut 59 (8), 1143–1153. gastroenterology 2004 18, 73–81. Fifth Chinese national consensus report on the management of Helicobacter pylori infection. With the increased antibiotic resistance of H. pylori, due to previous multiple exposures to antibiotics, elderly patients fail their intended eradication therapy. HT, high-dose dual therapy, BQT, bismuth quadruple therapy, ITT, intension-to-treat, PP, pre-protocol. Hirschl, A. M., and Rotter, M. L. (1996). Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux). There were no significant difference in the eradication rates in the ITT, mITT, and PP analysis between the 2 treatment groups. Rapid acid control may be achieved within an hour at an IV dose of 160 mg. HEPATIC: Liver function tests, especially in patients with impaired liver function, METABOLIC: Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy; Vitamin B12 levels, especially in patients on long-term therapy, MUSCULOSKELETAL: Bone fractures, especially in patients at high-risk for osteoporosis-related events. Equivalent efficacies of reverse hybrid and bismuth quadruple therapies in eradication of Helicobacter pylori infection in a randomized controlled trial. For patients unable to swallow a 40 mg tablet, two 20 mg tablets may be taken; however, the 40 mg oral suspension packet formulation should not be divided to create two-20 mg dosages. A study conducted by Zullo et al. The globally increasing antibiotic resistance in recent years is an important cause of first-line H pylori eradication failure (Graham and Fischbach, 2010). There is evidence that a dose of 3 g per day can achieve an effective eradication rate (Kwack et al., 2016; Li et al., 2021). (2017). FIGURE 1. High-dose esomeprazole and amoxicillin dual therapy for first-line Helicobacter pylori eradication: A proof of concept study. Store at room temperature away from light and moisture. Saudi J. gastroenterology official J. Saudi Gastroenterology Assoc. Der Test basiert auf zwei spezifischen monoklonalen Antikörpern gegen H . Selected from data included with permission and copyrighted by First Databank, Inc. 31 (9), 44–47. Do not over-fill the container. Do not start, stop, or change the dosage of any medicines without your doctor's approval. However, studies from the different regions show different cure rates, probably due to different dosages of PPI and amoxicillin (Graham et al., 2010; Kwack et al., 2016; Park et al., 2017). doi:10.3109/00365528909091311, Xie, Y., Zhang, Z., Hong, J., Liu, W., Lu, H., Du, Y., et al. This drug may be mixed with apple juice and administered via nasogastric tube. Ther. Gastroenterological Assoc. © 2005 - 2023 WebMD LLC, an Internet Brands company. The HT consisted of pantoprazole 40 mg 3 times daily and amoxicillin 1,000 mg 3 times daily for 14 days. (2018). doi:10.1053/j.gastro.2018.03.028, Li, C., Shi, Y., Suo, B., Tian, X., Zhou, L., and Song, Z. Proton pump inhibitors (such as pantoprazole) may increase your risk for bone fractures, especially with longer use, higher doses, and in older adults. We assumed an eradication rate of 90% in both the BQT and HT groups; with a non-inferiority margin delta (δ) = 0.1 (10%), α = 0.05 (two-sided), and 1-β = 0.90, we expected to recruit at least 75 patients per group (assuming a 10% loss to follow-up). Methods: Studies evaluating pantoprazole combined with antibiotics were considered. pantoprazole 40 mg tablet,delayed release, Select a condition to view a list of medication options. Maximum dose: 240 mg/day. (1989). TABLE 3. In general, elderly patients show a low tolerance and compliance to H. pylori eradication therapy (Salles and Mégraud, 2007). Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals. Drug interactions may change how your medications work or increase your risk for serious side effects. During pregnancy, this medication should be used only when clearly needed. Clin. Hsu, P. I., Tsay, F. W., Graham, D. Y., Tsai, T. J., Tsai, K. W., Kao, J. Y., et al. patients who were allergic to drugs related to medications. J. Gastroenterol. Dosage and length of treatment are based on your medical condition and response to treatment. 16 (9), 1427–1433. Helicobacter 24, e12596. Controlled studies using the oral formulation for maintenance did not extend beyond 12 months. Pediatric patients: Oral dose reductions should be considered. Moreover, the risk of adverse effects of H. pylori eradication therapy increases in elderly patients. Therefore, it is of practical significance to develop a safe and effective H. pylori eradication program for elderly patients, which is worthy of further study. pantoprazole 20 mg tablet,delayed release. jxsq2019201028) this writing assistance. Oral: Doses over 40 mg/day have not been studied in patients with liver impairment. Do not prepare the mixture ahead of time for later use. The pantoprazole-based eradication program was less affected by the CYP2C19 polymorphism (Fu et al., 2021). 40 kg and greater: 40 mg orally once a day Variety of adverse events in each regimen. The PPI potency has a strong ability to reliably maintain a relatively high intragastric pH. Eradication rates in each regimen. (2013). 15 (11), 622–627. If using this drug to treat H pylori, tell patients that it is important to complete the full regimen. Bismuth-containing quadruple therapy (BQT) is commonly used in China and is superior to the standard triple therapy (Xie et al., 2018). Several meta-analyses have compared the efficacy and safety of dual therapy and other regimens, and all of them concluded that PPI-amoxicillin is equally effective as other commonly used therapeutic regimens in the eradication of H. pylori (Gao et al., 2020a; Li et al., 2021). A very serious allergic reaction to this drug is rare. Adv. The chi-square test was used to determine the significance of differences between categorical variables and the t-test were used for continuous variables. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Therefore, high-dose dual therapy (HT) may be an effective eradication regimen for elderly patients who are not allergic to penicillin. This survey is being conducted by the WebMD marketing sciences department. Front. This medication relieves symptoms . It works by decreasing the amount of acid your stomach makes. In the US - Call your doctor for medical advice about side effects. 20 (4), 609–614. doi:10.14309/ajg.0000000000000132, Yang, J. C., Lin, C. J., Wang, H. L., Chen, J. D., Kao, J. Y., Shun, C. T., et al. (2018). IV treatment should be discontinued once the patient is able to take an oral formulation. Dis. (2014). Current management of Helicobacter pylori infections in the elderly. 114 (3), 437–445. HT was associated with fewer side effects (10.6% of patients) than BQT (26.6%) (p = 0.026). B., Li, P., Han, R., and Fang, D. C. (2017). Sprinkle the granules on 1 teaspoon (5 milliliters) of applesauce and swallow all of the mixture right away (within 10 minutes). 8217033301) for and grants from the Double-Thousand Plan of Jiangxi Province (No. Do not double the dose to catch up. Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as muscle spasms, irregular heartbeat, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain). Amoxicillin for the treatment of Helicobacter pylori infection. Rarely, proton pump inhibitors (such as pantoprazole) have caused vitamin B-12 deficiency. 5 (5), 845–856. Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet). fever, rash, or cold symptoms (most common in children). The prospective multiple-centre randomized controlled clinical study of high-dose amoxicillin-proton pump inhibitor dual therapy for H. pylori infection in Sichuan areas. If it is near the time of the next dose, skip the missed dose. Clin. Successful eradication was achieved in 10 of these patients. Canada residents can call a provincial poison control center. Enter your medication into the WebMD interaction checker. This medicine is a yellow, oval, enteric-coated, tablet imprinted with "H125". doi:10.2217/pgs-2020-0127, Gao, C. P., Zhang, D., Zhang, T., Wang, J. X., Han, S. X., Graham, D. Y., et al. (2016). Infektionen mit Helicobacter pylori verursachen häufig eine akute Gastritis und sind so ein Risikofaktor für . This is not a complete list of possible side effects. Lancet (London, Engl. J. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Tablet formulations should be swallowed whole, without crushing/chewing; tablets may be taken with or without food. Methods: This was a single-center, randomized study of 150 elderly patients with H. pylori infection who were randomly assigned to 14-day therapy with pantoprazole 40 mg 3 times daily and either amoxicillin 1,000 mg 3 times daily or amoxicillin 1,000 mg twice daily, clarithromycin 500 mg twice daily and bismuth 220 mg twice daily. This drug may be used concomitantly with antacids without affecting the absorption. (2020). This was also a single-center study. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors.